Not to my knowledge. Sections 245a and 245b clearly state the requirements for being able to adjust status, and prevent anyone who did not enter legally, fell out of status or worked illegally from adjusting. Part of Section 245c (I believe, I may have the subsections wrong) exempts immediate relatives from the out of status/illegal employment prohibition, Section 245k exempts EB beneficiaries from being out of status or illegally employed if it was 180 days or less, and then 245i exempts folks with a PD of 4/30/2001 or before who file the I-485A and pay the fine.
If the AOs had the discretion to waive the bars in without an approved I-601 waiver petition, they would do so and we don't need 245i at all. Unfortunately, the INA to my knowledge has statutory language as to how the waivers can be obtained, and the AOs cannot ignore that either.
Being a nation of laws versus men cuts both ways, but overall it is a good thing.