Yes listing different home addresses on your AOS forms matters, it means you’ll get different interview dates in different locations. If the derivative’s case get scheduled before the main selectee, that interview will either not proceed or if it proceeds, it will not be approved until after the main selectee has been interviewed and approved.
And I’m assuming she’s planning on moving before you guys file. If you guys move after filing, you introduce some delays into your case as USCIS will need to transfer your case file to the new FO with jurisdiction over wherever you move to.
The genuineness of your marriage could also come under close scrutiny, so be prepared to proof your marriage is genuine.