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As long as your I-485 is pending, you are in status and are eligible to use EAD to work for any employer. Alternatively, you can ask your new company to petition for a new H1B. There are pros and cons for either method. If you use your EAD, in the unlikely event that your I-485 is adjudicated within 180 days, your will be out of status and can no longer work in the US. On the other hand, if you get a new H1B using the AC21 portability rule, then you are likely to get RFE and a possible interview. However, the tricky question is whether your I-485 is still valid if you change job before 180 days. AC21 is vague and INS hasn\'t clarified this. Being Optimistic, I would say your I-485 will still be approved as long as you find a new job in similar job category. If you have no other choice, use your EAD.