Based on my understanding, the moment you file your 485 and get the Receipt Notice from INS you're IN STATUS, i.e., status as an alien waiting to adjust status to a permanent resident. The EAD allows you to work for any employer in the US, and Federal and state laws prohibit employers from discriminating against persons holding an EAD. If any employer refuses an EAD and denies you work, you could sue them. Anyway, coming back to the subject, as far as I know there shouldn't be any problems but you might want to check with your lawyer or INS whether your wife can join school in your current status, i.e., 485 w/EAD.