Will my F-1 visa be denied if I apply after returning to my home country?

[Ravery]

I've been in the U.S. for approximately 10 years on three different visas (A-2, F-2, and F-1). My OPT will be expiring soon and I'll have to return to my home country. My mother has her green card, my brother is a U.S. citizen, and we plan to apply for my father's green card soon.
If I apply for a new visa for a US master's program while I'm in my home country, would the USCIS deny my application because my visa history and family background indicates that I have "intentions to immigrate" based on the Immigration and Nationality Act?

 

[Hexa]

That risk exists, especially since you have immediate family members in USA. If at all possible, you should apply for a new I-20 for the master's program here instead of from your home country. If your previous F-1 was for an undergraduate degree, USCIS won't see it as unusual that you want to continue with another F-1 for a graduate degree.