Here is how I look at it. Your biwi will get her GC one day. Either way her 485 will be filed, she will have EAD and AP by virtue of that. You have a 485 approved, so you don't need to maintain the 100% employment record like we unapproved folks do.
SO go ahead change jobs. Worst case if her case gets transferred or issues get created, even then, one day YOU will become citizen, and file for her GC, meanwhile she lives here and works here legally.
Right Vipsha?