If it is due to the facility closing, you are fine. If you want to change by your own volition, it is very difficult. So, if your employer cooperates by giving you a letter stating that they are closing, it is not a big problem.
If you stay in the same state, you should probably talk to the department of health to get their ok. (some states have these odd 6 month advertisement requirements, I don't know how they would deal with a change in plan).
If you move to a different state, it is a bit more complicated. I believe you need a new 'slot', but I am not sure. In any case, the new state has to sponsor you in one way or another (don't know whether you have to go back to DOS, but I could ask a friend who did the change).