US government recognizes that PIO and OCI cards are not Indian citizenship, just long term visas to visit India. Security clearance have several requirements and just having an OCI /PIO card is not in itself a disqualification.
see http://travel.state.gov/travel/cis_pa_tw/cis/cis_1139.html, scroll down to "Special Circumstances" section.
no there is no side effect on getting security clearance if you have OCI or PIO. I checked with my fellow lawyer friend a long time ago and she mentioned not to worry about it.
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