Technically yes,
I might be wrong, but the pattern i saw for most of the case (including mine) for the concurrent filer, mostly EAD get approved after I-140 approval. so mostly that doesn't happen.
If it does happen (denied I-140 after using EAD), usually before denied I-140/ I-485 they send couple (or atleast 2 as I think) of REF, and if you don't reply satisfactory then they can denied I-140, so I think it will invalidate I-485 application and I think you might have apply for h4(I-539) again or reenter to usa to get new I-94 form (mostly). There are lots of gray area, and I am not legal expert, but this is my guess. please consult your lawyer.
Good luck,
JB