I doubt it
It may be true for H1s, but I don\'t think company size matters during 485 processing. If you are in 485 means finishing of labor certification and 140 which are major hurdles than 485 processing where they only concerned about few things (criminal history, status, priority dates etc minor things). Rejection percentage is very less compare to recent H1 RFE\'s.
I work for one of the fortune 100 companies (about 80000 employees), and Still I\'ve seen few of my colleagues getting RFEs. So size doesn\'t matter.