I'm in a similar situation, my wife is also a cancer patient, and I'm trying to extend my mother-in-law's stay. I filed I-539 for that. I don't know the answer to your question but as far as I know visiting canada or mexico does not extend your I94. You may want to double check that before...
My wife was diagnosed with advanced stage breast cancer and her prognosis is very poor. My mother-in-law came to US to help us. Her i94 is going to expire on July 10.
I filed for an extension of stay of 5 months, and the application was delivered (delivery signature confirmation) on 6/10/11...
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