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Cogniflex Be sure to de-stress your life if you are battling any sort of depression. Stress can keep depression in play and even worsen your condition. What is making you so tense? This will help you figure out how to minimize the things that stress you outAvoid self medicating with over the counter or illicit drugs or alcohol. When people experience depression they often turn to drugs and alcohol to make the problems go away, but in reality it really just makes things a lot worse. Often, taking drugs or drinking alcohol can lead to dependency.